Oops! Sorry!!


This site doesn't support Internet Explorer. Please use a modern browser like Chrome, Firefox or Edge.

The Science Behind Combat Creatine™ | 10 Clinically Dosed Ingredients
🔬 Peer-Reviewed Science

The Research
Is Compelling.
Here's Why.

Regular creatine supports your muscles, but research suggests your brain may be the limiting factor. Combat Creatine™ adds 9 evidence-backed ingredients designed to address both. Here's exactly what the science shows.

10
Active Ingredients
50+
Clinical Studies
0
Proprietary Blends
cGMP Certified Facility
NSF Certified Facility
Third-Party Tested
Non-GMO
Vegan
Zero Prop. Blends
The Problem With Standard Creatine

Your Muscles Get Fuel.
Your Brain Gets Nothing.

01
Creatine may support strength, but focus can still fade mid-session

Your Muscles and Brain Have Different Needs

Creatine is one of the most studied compounds in sports science. Research consistently associates it with improvements in strength, power, and even cognitive performance via the blood-brain barrier. But it was never designed to address sustained focus under fatigue, stress-driven motivation drops, or the neurotransmitter depletion that may cause mental output to decline before muscles do. That requires a different approach entirely.

02
Intense training is associated with cortisol spikes, which may blunt your drive

Stress Hormones May Be Limiting Your Sessions

Intense training is associated with elevated cortisol. Research suggests cortisol can deplete dopamine precursors — and depleted dopamine is linked to reduced motivation and focus. Without adaptogenic support, this hormonal response may degrade output over the course of a session and slow recovery between them. Creatine alone doesn't address this pathway.

03
Research suggests the brain may give up before the muscles do

Neural Fatigue May Set In Before Muscle Fatigue Does

Studies indicate that neurotransmitter depletion (acetylcholine, dopamine, norepinephrine) may contribute to what athletes describe as "hitting the wall," even when physical capacity remains. A formula that addresses only the muscular side of performance leaves this potential limiter unaddressed.

💡

The fix: Research points to peak performance as a brain-body system. Combat Creatine™ is designed to deliver creatine plus the cognitive and adaptogenic ingredients that may support both sides of that equation — from the first rep to the last decision of your day.

Full Transparent Formula · No Proprietary Blends

10 Ingredients.
Zero Fillers.

Every ingredient is at the exact dose used in peer-reviewed human studies. Not a milligram more for label appeal. Not a milligram less to cut costs.

Each card: the benefit you feel first. The science behind it below.

Creatine Monohydrate
5,000 MG

⚡ Strength & Power

May support more reps, more power, and faster recovery.[1,2]

Research suggests creatine saturates muscle phosphocreatine stores to support faster ATP regeneration, the fuel behind explosive efforts. Studies associate this with increased reps, heavier loads, and greater total output capacity.

The most studied performance compound in sports science, with 500+ peer-reviewed human studies. 5g/day is the widely used maintenance dose.[1] Research also suggests creatine crosses the blood-brain barrier and may support memory and cognitive performance alongside physical output.[2]

500+peer-reviewed human studies. Most studied compound in sports science.
L-Tyrosine
1,500 MG

🧠 Cognitive Focus

May help maintain focus and drive when fatigue sets in.[3]

Intense training is associated with depletion of dopamine, norepinephrine, and epinephrine — neurotransmitters linked to motivation and focus. L-Tyrosine is the direct precursor to all three. Research suggests it may help replenish catecholamine levels under physical and psychological stress.

1,000–2,000mg is the dose range used in peer-reviewed studies on cognitive performance under stress. This formula uses 1,500mg, within that studied range.[3]

Evidence
Solid
Brain Res BullJ Psychiatr Res
Acetyl-L-Carnitine
1,000 MG

⚡ Energy & Clarity

May support sustained energy and mental clarity through your session.[4]

Transports fatty acids into your mitochondria for sustained cellular energy production that doesn't crash. It also reduces the metabolic fatigue responsible for that performance cliff in the second half of training. You don't just start strong; you stay strong.

ALCAR's acetyl group donates to acetylcholine synthesis, adding a cognitive sharpness benefit on top of its energy role. Two mechanisms, one ingredient, one clinical dose.

Dual-action compound: energy and acetylcholine synthesis confirmed in separate peer-reviewed mechanisms.
Am J Clin NutrDrugs R D
Lion's Mane Extract
1,000 MG

🧠 Nerve Growth Factor

Research suggests cognitive speed and mood may improve with consistent use.[5]

Lion's Mane has been shown in studies to stimulate Nerve Growth Factor (NGF), a protein associated with neuron maintenance and new neural connection formation. Research suggests these effects may build over weeks of consistent use, rather than producing a one-time stimulant effect.

A 2023 double-blind, placebo-controlled trial in Nutrients found significant improvements in cognitive speed and mood in young adults. Effects accumulate with consistent use.

2023 RCT in Nutrients: double-blind, placebo-controlled. Significant improvements in cognitive speed & mood.
Alpha-GPC
600 MG

🧠 Acetylcholine & Power

Associated with sharper mind-muscle connection and measurable power gains.[6]

The most bioavailable choline source available. Raises acetylcholine, the neurotransmitter that governs muscle contraction, coordination, and reaction speed. Better acetylcholine means every rep is more intentional and more forceful.

Alpha-GPC at 600mg has been shown in one study to be associated with approximately 14% greater peak power output vs. placebo in resistance-trained athletes.[6] The same mechanism supports acetylcholine synthesis for cognitive benefit.

+14%
peak power output vs. placebo in resistance-trained athletes at this dose.
Uridine 5'-Monophosphate
400 MG

🧠 Synapse Formation

May support neural adaptation and synapse formation over time.[7]

Uridine is a key building block of neuronal membranes and a driver of new synapse formation. Paired with Alpha-GPC above, it creates a pathway your brain uses to build new neural connections, accelerating the kind of adaptation that makes high-pressure performance feel easier over time.

Wurtman et al. at MIT identified the Uridine + Choline pairing as a synergistic driver of brain synapse formation, one of the more compelling nutrient-neuroscience findings of the last decade.

Wurtman et al., MIT: Uridine + Choline identified as a synergistic driver of brain synapse formation.
Phosphatidylserine
300 MG

🛡️ Cortisol Control

Associated with reduced cortisol during exercise. May help protect focus mid-session.[8]

Phosphatidylserine is a phospholipid naturally found in your brain cells. During intense exercise, it suppresses cortisol release, the stress hormone that degrades focus, decision-making, and motivation when it spikes too high. Less cortisol mid-session means your mental output curve doesn't crater in the back half.

Multiple RCTs have found 300–400mg PS to be associated with reductions in exercise-induced cortisol of up to 30%, with reported effects on sports performance and cognitive function.[8]

−30%
exercise-induced cortisol reduction in multiple RCTs at 300–400mg.
Bacopa Monnieri
300 MG

🧠 Memory & Cognition

Research associates it with improved memory, processing speed, and cognitive recall.[9,10]

Bacopa enhances the synthesis, repair, and signaling of neurons responsible for memory and learning. Athletes who absorb technique faster, retain it under fatigue, and adapt to training stimuli more efficiently. Bacopa is the compound that supports that.

Multiple double-blind RCTs confirm improvements in memory formation speed, cognitive processing, and recall under stress. Effects build over 4–8 weeks of consistent use.

Evidence
Strong
NeuropsychopharmacologyPhytotherapy Research
Ashwagandha
300 MG

🛡️ Adaptogen · Stress & Recovery

Studied adaptogen associated with strength, recovery, and stress regulation.[11,12]

One of the most extensively studied adaptogens in sports science. Research associates ashwagandha with reduced cortisol response, maintained testosterone levels, and improved recovery markers between sessions. A 2021 Bayesian meta-analysis found significant improvements in VO2 max, strength, and recovery.[11]

A 2021 Bayesian meta-analysis published in JFMK found statistically significant improvements in VO2 max, strength, and recovery markers. Backed by multiple well-designed RCTs.

2021 Bayesian meta-analysis (JFMK): Significant improvements in VO2 max, strength, and recovery markers across multiple RCTs.
L-Theanine
200 MG

🛡️ Calm Focus

May promote calm, focused attention without overstimulation or crash.[13]

L-Theanine promotes alpha-wave brain activity, the neural state of calm, deliberate, focused attention. It counteracts the anxious edge that can come with a high-performance cognitive stack, balancing the formula so you get precision focus without overstimulation and no crash when it wears off.

Well-documented to modulate the effects of catecholaminergic compounds, making L-Theanine the ideal finishing agent in a multi-nootropic formula. No sedation. No crash. Just precision.

Evidence
Solid
Nutr NeurosciAsia Pac J Clin Nutr
Why the Combination Matters

Each Ingredient Is Good.
Together They're Different.

These aren't ten separate supplements randomly combined. They're engineered to work in specific pairs, each one amplifying the next.

Creatine + Alpha-GPC

Strength Meets Precision

More power, better control

Creatine loads your muscles with fuel. Alpha-GPC sharpens the neural signal that fires those muscles. The result isn't just stronger. It's more intentional and more efficient from rep one.

Alpha-GPC + Uridine

Your Brain Builds New Connections

Neural adaptation accelerates

Alpha-GPC provides choline. Uridine provides the structural material. Together they trigger the phosphatidylcholine synthesis pathway, literally helping your brain form new synapses faster under pressure.

Ashwagandha + Phosphatidylserine

Cortisol Gets Controlled From Both Ends

Stress doesn't tank your session

Ashwagandha regulates the HPA axis, your body's central stress control system. PS suppresses the cortisol spike during exercise directly. Together they prevent the hormonal cascade that destroys motivation mid-set.

L-Tyrosine + L-Theanine

Sharp Focus Without the Anxiety

Driven, calm, and dialed in

Tyrosine refills the dopamine and norepinephrine your session burns through. Theanine smooths the edge so you stay dialed in without overstimulation. Clean mental performance from start to finish.

Peer-Reviewed Literature

The Research
It's Built On

[1, 2] Creatine Monohydrate: Cognitive & Physical Performance Prokopidis K, et al. (2022). Effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis. Nutritional Neuroscience. Dolan E, et al. (2019). Beyond muscle: the effects of creatine supplementation on brain creatine, cognitive processing, and traumatic brain injury. European Journal of Sport Science.
[3] L-Tyrosine: Cognitive Performance Under Stress Jongkees BJ, et al. (2015). Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands: a review. Journal of Psychiatric Research.
[5] Lion's Mane: Cognitive Speed, Mood & NGF Stimulation Docherty S, et al. (2023). The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Placebo-Controlled Trial. Nutrients.
[6] Alpha-GPC: Acetylcholine & Power Output Marcus L, et al. (2024). Acute Alpha-GPC Supplementation Enhances Cognitive Performance in Healthy Men. Journal of the International Society of Sports Nutrition.
[7] Uridine: Synapse Formation Wurtman RJ, et al. (2014). Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase brain synapse formation. Nutrition Reviews.
[9, 10] Bacopa Monnieri: Memory & Cognitive Attention Kumar N, et al. (2016). Efficacy of Standardized Extract of Bacopa monnieri on Cognitive Functions. Evidence-Based Complementary and Alternative Medicine. Brimson JM, et al. (2021). The effectiveness of Bacopa monnieri for cognitive enhancement and mental health. Phytotherapy Research.
[11, 12] Ashwagandha: Stress, Strength & Recovery Bonilla DA, et al. (2021). Effects of Ashwagandha on Physical Performance: Systematic Review and Bayesian Meta-Analysis. Journal of Functional Morphology and Kinesiology. Mikulska P, et al. (2023). Ashwagandha (Withania somnifera): Current Research on Health-Promoting Activities. Pharmaceutics.
[4] Acetyl-L-Carnitine: Energy & Acetylcholine Synthesis Malaguarnera M, et al. (2007). L-Carnitine treatment reduces severity of physical and mental fatigue. The American Journal of Clinical Nutrition.
[8] Phosphatidylserine: Cortisol & Sports Performance Starks MA, et al. (2008). The effects of phosphatidylserine on endocrine response to moderate intensity exercise. Journal of the International Society of Sports Nutrition.
[13] L-Theanine: Focus & Calm Attention Kimura K, et al. (2007). L-Theanine reduces psychological and physiological stress responses. Biological Psychology.

You’ve Seen the Research.
You’ve Read the Formula.
Try It Risk-Free.

10 evidence-backed ingredients. 50+ studies. 60 days to find out if it works for you.

🔒 60-Day Money-Back Guarantee. Completely Risk-Free.

© Combat Creatine™. All rights reserved.  ·  combatcreatine.com

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.